Papa lāʻau lapaʻau ʻo Medium-Chain Triglycerides (MCT) | Lipophilic Solvent & Drug Carrier no ka waha/Topical/Injectable | USP/EP/ChP

ʻO kā mākou Medium-Chain Triglycerides (MCT) kahi mea hoʻohui lāʻau lapaʻau kiʻekiʻe i haku ʻia me nā triglycerides o ka saturated caprylic (C8) a me nā capric (C10) fatty acids, i loaʻa mai ka niu a me nā aila niu pamaʻIke ʻia ia he wai ʻaila maopopo, ʻaʻohe kala a melemele iki paha, haʻahaʻa ka mānoanoa me kahi ʻala a me ka ʻono kūlike ʻole.Hana ʻo MCT ma ke ʻano he mea hoʻoheheʻe maikaʻi loa no nā lāʻau lipophilic, mea lawe lāʻau no ka bioavailability i hoʻonui ʻia, emollient no nā ʻano topical, a me ka mea hoʻonui komo no ka lawe ʻana i ka dermal.Hāʻawi ia i ke kūpaʻa oxidative kiʻekiʻe loa, ka omo wikiwiki (kaʻapuni pololei ʻana o ka puka me ka ʻole o ka paʻakai bile), a me ka hoʻohālikelike maikaʻi loa me nā API a me nā mea hoʻohui ʻē aʻeKūlike me nā lāʻau lapaʻau USP-NF, EP, JP, a me ChP me ka hoʻopaʻa inoa CDE F20220000316. Kūpono no nā hopena waha/capsules, nā kirīmi/ʻaila topical, ka meaʻai parenteral, a me nā ʻōnaehana hoʻouna lāʻau hoʻoheheʻe ponoʻī (SEDDS).

Kāhea iā mā˚ou

Nā kikoʻī huahana

Nā Triglycerides Kaulahao Waena (MCT) Papa Lāʻau Lapaʻau

ʻIke Huahana

ʻO ka Medium-Chain Triglycerides (MCT) kahi mea hoʻohui lāʻau lapaʻau i hoʻokumu maikaʻi ʻia i loko o ka hui ʻana o nā triglycerides o nā waikawa momona saturated, ʻo ia hoʻi ka waikawa caprylic (C8H16O2, waikawa octanoic) a me ka waikawa capric (C10H20O2, waikawa decanoic).Loaʻa kēia mau triglycerides mai ka ʻaila paʻa i unuhi ʻia mai ka ʻāpana paʻakikī a maloʻo o ka endosperm o ka niu (Cocos nucifera L.) a i ʻole mai ka endosperm maloʻo o ka niu pama (Elaeis guineensis Jacq.)Hoʻokaʻawale ʻia nā waikawa momona mai ka ʻaila momona a hoʻohui hou ʻia me ka glycerol e hana i ka huahana hope loa..

ʻIke Huahana:

Inoa Kemika:Nā Triglycerides Kaulahao Waena / Caprylic/Capric Triglyceride
Helu CAS:73398-61-5 (a me 85409-09-2 a i ʻole 538-24-9)
Helu Hoʻopaʻa Inoa CDE:F20220000316
Hoʻokō ʻana i ka Pharmacopoeia:ChP (CP2020), USP-NF (Nā Triglycerides Kaulahao Waena), EP (Nā Triglycerides, Kaulahao Waena), JP (Triglycerides waikawa momona kaulahao waena)
Nā huaʻōlelo like:ʻAila MCT, Caprylic/Capric Triglyceride, Glycerides i hui pū ʻia me decanoyl a me octanoyl, Miglyol® 812 like, Labrafac™ CC like
ʻAno:ʻAʻohe kala a i ʻole wai ʻaila melemele iki, aneane ʻaʻohe ala a ʻaʻohe ʻono
Kiko Paʻahau:Ma kahi o 0°C

Nā Hiʻohiʻona Koʻikoʻi a me nā Pōmaikaʻi

1. Nā ʻano hoʻoheheʻe kiʻekiʻe loa

He mea hoʻoheheʻe maikaʻi loa no nā lāʻau lipophilic a me nā API wai-hoʻoheheʻe maikaʻi ʻole
Hoʻonui i ka solubilization a me ka hoʻopaʻa ʻana o nā pūhui lipophilic
Hoʻomaikaʻi i ka bioavailability o nā lāʻau lapaʻau Class II a me Class IV (ka hoʻokaʻawale ʻana o BCS)

2. Ka Omo wikiwiki ʻana a me ka Metabolism

Hoʻopili pololei ʻia i loko o ke kaʻina hana portal me ka ʻole o ka pono no nā paʻakai bile a i ʻole nā enzymes pancreatic
Hoʻopili koke ʻia e hāʻawi i ka ikehu wikiwiki
ʻO ka wikiwiki o ka hoʻouna ʻana o ka API i ke kaʻapuni ʻōnaehana, hiki ke hoʻomaikaʻi i ka hoʻomaka ʻana o ka hana

3. ʻIke Kūlana Paʻa Maikaʻi Loa

Ke kūpaʻa kiʻekiʻe i ka oxidation (waiwai iodine ≤1.0)
Haʻahaʻa ka maʻalahi i ke kaumaha wela a me ka oxidative
Mālama i ke kūpaʻa a me ke ola papa o nā ʻano lāʻau lapaʻau
Paʻa ma nā ʻano mahana like ʻole (≤25°C i manaʻo ʻia)

4. Nā Waiwai Kino Kiʻekiʻe Loa

Mānoanoa:~30 mPa·s ma 20°C (mānoanoa haʻahaʻa no ka lawelawe maʻalahi)
Ka Umekaumaha Kūikawā:0.93-0.96 ma 20°C
Papa Kuhikuhi Refractive:1.440-1.452 ma 20°C
Haʻahaʻa ka mānoanoa kūpono no nā ʻano lāʻau wai a me nā ʻano semi-paʻa

5. Hoʻohālikelike maikaʻi loa

Kūlike me nā ʻano API like ʻole a me nā mea hoʻohui lāʻau lapaʻau
Hiki ke hoʻohui maʻalahi i loko o nā ʻano hana like ʻole me ka ʻole o nā pilikia hoʻohālikelike
ʻAla a me ka ʻono kūlike ʻole - kūpono no nā ʻano hana waha kahi e pono ai ka palatability

6. ʻIkepili Hoʻoponopono a me ka Palekana